BD-PN2563

NPSR1 Rabbit Polyclonal Antibody

常规抗体

NPSR1 GPR154 GPRA PGR14

Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

387129

Q6W5P4

https://www.uniprot.org/uniprotkb/Q6W5P4/entry

Q8BZP8

http://www.uniprot.org/uniprot/Q8BZP8

P0C0L6

http://www.uniprot.org/uniprot/O54941P0C0L6

Synthesized peptide derived from part region of human protein

NPSR1 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

40kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients.

[Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 3]: Cell membrane ; Multi-pass membrane protein .; [Isoform 4]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Cytoplasm .; [Isoform 5]: Cytoplasm .; [Isoform 6]: Cytoplasm .; [Isoform 7]: Cytoplasm .; [Isoform 9]: Cytoplasm .

disease:NPSR1 is associated with susceptibility to asthma and elevated serum IgE levels [MIM:608584]. Polymorphisms may influence the development of asthma and bronchial hyperresponsiveness in adult, and are significantly associated with allergic sensitization and rhinoconjunctivis, as well as asthma in children.,function:May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases.,miscellaneous:Only isoforms with 7 transmembrane topology (isoform 1, isoform 3 and isoform 4) are transported into the plasma membrane in transfected cells, while the truncated ones retain intracellular compartments.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Ubiquitous. Isoform 1 is predominantly expressed in smooth muscle, and isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, isoform 4 is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, isoform 4 expression is consistently stronger in asthma patients.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.