产品名称
MCHR1 Rabbit Polyclonal Antibody
蛋白名称
Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q99705
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99705/entry
Mouse Swissprot No.
Q8JZL2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8JZL2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97639
免疫原
Synthesized peptide derived from part region of human protein
特异性
MCHR1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
melanin concentrating hormone receptor 1(MCHR1) Homo sapiens The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008],
组织表达
Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
caution:It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.,function:Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with NCDN.,tissue specificity:Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
