产品名称
GPR64 Rabbit Polyclonal Antibody
蛋白名称
G-protein coupled receptor 64 (Human epididymis-specific protein 6) (He6)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IZP9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IZP9/entry
Mouse Swissprot No.
Q8CJ12
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CJ12
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8CJ11
免疫原
Synthesized peptide derived from part region of human protein
特异性
GPR64 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],
组织表达
Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung.
细胞定位
Apical cell membrane ; Multi-pass membrane protein .
功能
function:Could be involved in a signal transduction pathway controlling epididymal function and male fertility.,PTM:Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit .,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,subunit:Forms a heterodimer, consisting of a large extracellular region linked to a seven-transmembrane moiety.,tissue specificity:Epididymis specific. Both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
