产品名称
GPR33 Rabbit Polyclonal Antibody
蛋白名称
Probable G-protein coupled receptor 33
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q49SQ1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q49SQ1/entry
Mouse Swissprot No.
O88416
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88416
免疫原
Synthesized peptide derived from part region of human protein
特异性
GPR33 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010],
组织表达
Expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads and leukocytes.
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
function:Orphan receptor; could be a chemoattractant receptor.,polymorphism:In most individuals a nonsense mutation transforms the Arg-140 into a premature stop codon. Out of 1217 individuals, 1166 had a stop codon in both alleles, 50 were heterozygous and only one (in the Philippines) had Arg-140 in both alleles. GPR33 has undergone independent pseudogenization in human, chimpanzee, orangutan, siamang and rat. This selective inactivation may be due to its interaction with a putative pathogen that could use GPR33 as a receptor for cell invasion.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads and leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
