产品名称
HEM1 Rabbit Polyclonal Antibody
基因名称
ALAS1 ALAS3 ALASH OK/SW-cl.121
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/211
Human Swissprot No.
P13196
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P13196/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/11655
Mouse Swissprot No.
Q8VC19
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VC19
Rat Gene Link
https://www.uniprot.org/uniprot/65155
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P13195
免疫原
Synthesized peptide derived from human HEM1 AA range: 87-137
特异性
This antibody detects endogenous levels of HEM1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015],
细胞定位
Mitochondrion inner membrane ; Peripheral membrane protein . Localizes to the matrix side of the mitochondrion inner membrane. .
功能
catalytic activity:Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2).,cofactor:Pyridoxal phosphate.,miscellaneous:There are two delta-ALA synthetase in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.,pathway:Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.,similarity:Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.