产品名称
SSR3 Rabbit Polyclonal Antibody
蛋白名称
Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SSR-28)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P32745
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P32745/entry
Mouse Swissprot No.
P30935
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P30935
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P30936
免疫原
Synthesized peptide derived from human protein . at AA range: 340-420
特异性
SSR3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
组织表达
Brain, pituitary and pancreas.
细胞定位
Cell membrane ; Multi-pass membrane protein . Internalized into endoplasmic vesicles upon somatostatin-stimulation. .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.,PTM:Phosphorylated. Phosphorylation increases upon somatostatin binding.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Internalized into endoplasmic vesicles upon somatostatin-stimulation.,tissue specificity:Brain, pituitary and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
