产品名称
GP183 Rabbit Polyclonal Antibody
蛋白名称
G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P32249
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P32249/entry
Mouse Swissprot No.
Q3U6B2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3U6B2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941D4A7K7
免疫原
Synthesized peptide derived from human protein . at AA range: 110-190
特异性
GP183 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008],
组织表达
Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes (PubMed:16540462, PubMed:8383238). Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain (PubMed:16540462, PubMed:8383238). Expressed in astrocytes (PubMed:25297897).
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
caution:It is uncertain whether Met-1 or Met-5 is the initiator.,function:Orphan receptor. Probable mediator of EBV effects on B lymphocytes or of normal lymphocyte functions. Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha.,induction:By EBV.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
