产品名称
GPR33 Rabbit Polyclonal Antibody
蛋白名称
Probable G-protein coupled receptor 33
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q49SQ1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q49SQ1/entry
Mouse Swissprot No.
O88416
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88416
免疫原
Synthesized peptide derived from part region of human protein
特异性
GPR33 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010],
组织表达
Expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads and leukocytes.
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
function:Orphan receptor; could be a chemoattractant receptor.,polymorphism:In most individuals a nonsense mutation transforms the Arg-140 into a premature stop codon. Out of 1217 individuals, 1166 had a stop codon in both alleles, 50 were heterozygous and only one (in the Philippines) had Arg-140 in both alleles. GPR33 has undergone independent pseudogenization in human, chimpanzee, orangutan, siamang and rat. This selective inactivation may be due to its interaction with a putative pathogen that could use GPR33 as a receptor for cell invasion.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads and leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
