产品名称
OXGR1 Rabbit Polyclonal Antibody
基因名称
OXGR1 GPR80 GPR99 P2RY15 P2Y15
蛋白名称
2-oxoglutarate receptor 1 (Alpha-ketoglutarate receptor 1) (G-protein coupled receptor 80) (G-protein coupled receptor 99) (P2Y purinoceptor 15) (P2Y15) (P2Y-like GPCR) (P2Y-like nucleotide receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96P68
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96P68/entry
Mouse Swissprot No.
Q6IYF8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6IYF8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6Y1R5
免疫原
Synthesized peptide derived from human protein . at AA range: 130-210
特异性
OXGR1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016],
组织表达
Detected in kidney and, to a lower extent, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons.
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
caution:Was originally (Ref.5) thought to be a P2Y receptor.,function:Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Detected in kidney and, to a lower extend, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
