产品名称
GPR78 Rabbit Polyclonal Antibody
基因名称
GPR78 UNQ5925/PRO19818
蛋白名称
G-protein coupled receptor 78
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96P69
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96P69/entry
免疫原
Synthesized peptide derived from human protein . at AA range: 290-370
特异性
GPR78 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011],
组织表达
High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
function:Orphan receptor.,induction:Expression increased in fibroblasts or HeLa cells following UV-A irradiation, exposure to DNA-alkylating agents, or endoplasmic reticulum (ER) stress caused by osmotic shock or the glycosylation inhibitor tunicamycin.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in pituitary and placenta. No expression detected in brain, skeletal muscle, lung, heart, liver, pancreas, or kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
