产品名称
GPR3 Rabbit Polyclonal Antibody
蛋白名称
G-protein coupled receptor 3 (ACCA orphan receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P46089
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P46089/entry
Mouse Swissprot No.
P35413
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P35413
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8K1Q3
免疫原
Synthesized peptide derived from human protein . at AA range: 260-340
特异性
GPR3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012],
组织表达
Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
function:Orphan receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
