产品名称
GP161 Rabbit Polyclonal Antibody
蛋白名称
G-protein coupled receptor 161 (G-protein coupled receptor RE2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8N6U8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N6U8/entry
Mouse Swissprot No.
B2RPY5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/B2RPY5
免疫原
Synthesized peptide derived from human protein . at AA range: 180-260
特异性
GP161 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]).[supplied by OMIM, Aug 2008],
组织表达
Brain,Fetal brain,Teratocarcinoma,Tongue,
细胞定位
Cell projection, cilium membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). .
功能
function:Orphan receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
