产品名称
DRD2 Rabbit Polyclonal Antibody
蛋白名称
D(2) dopamine receptor (Dopamine D2 receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P14416
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P14416/entry
Mouse Swissprot No.
P61168
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P61168
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P61169
免疫原
Synthesized peptide derived from human protein . at AA range: 170-250
特异性
DRD2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008],
组织表达
[Isoform 1]: Expressed in the anterior pituitary gland. ; [Isoform 2]: Expressed in the anterior pituitary gland.
细胞定位
Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .
信号通路
Neuroactive ligand-receptor interaction;Gap junction;
功能
disease:Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.,disease:It has been suggested that DRD2 is involved in psychiatric disorders; especially in schizophrenia.,function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,polymorphism:Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
