产品名称
CCR9 Rabbit Polyclonal Antibody
蛋白名称
C-C chemokine receptor type 9 (C-C CKR-9) (CC-CKR-9) (CCR-9) (G-protein coupled receptor 28) (GPR-9-6) (CD antigen CDw199)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P51686
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P51686/entry
Mouse Swissprot No.
Q9WUT7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WUT7
免疫原
Synthesized peptide derived from human protein . at AA range: 140-220
特异性
CCR9 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
组织表达
Highly expressed in the thymus and low in lymph nodes and spleen.
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Cytokine-cytokine receptor interaction;Chemokine;Intestinal immune network for IgA production;
功能
function:Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.,miscellaneous:EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2.,online information:CC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highly expressed in the thymus and low in lymph nodes and spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
