产品名称
CCR8 Rabbit Polyclonal Antibody
基因名称
CCR8 CKRL1 CMKBR8 CMKBRL2
蛋白名称
C-C chemokine receptor type 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) (CC chemokine receptor CHEMR1) (CMKBRL2) (Chemokine receptor-like 1) (CKR-L1) (GPR-CY6) (GPRCY6) (TER1) (CD antigen CDw198)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P51685
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P51685/entry
Mouse Swissprot No.
P56484
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P56484
免疫原
Synthesized peptide derived from human protein . at AA range: 250-330
特异性
CCR8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008],
组织表达
PCR rescued clones,Thymus,
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Cytokine-cytokine receptor interaction;Chemokine;
功能
caution:Was originally (PubMed:9521068) thought to be a receptor for SCYA3 and SCYA17.,function:Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.,online information:CC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
