产品名称
PSA6 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5687
Human Swissprot No.
P60900
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P60900/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/26443
Mouse Swissprot No.
Q9QUM9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QUM9
Rat Gene Link
https://www.uniprot.org/uniprot/29673
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P60901
免疫原
Synthesized peptide derived from human PSA6 AA range: 70-120
特异性
This antibody detects endogenous levels of PSA6 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013],
细胞定位
Cytoplasm . Nucleus . Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951). Colocalizes with TRIM5 in cytoplasmic bodies (By similarity). .
功能
catalytic activity:Cleavage of peptide bonds with very broad specificity.,function:The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.,similarity:Belongs to the peptidase T1A family.,subunit:The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
