产品名称
CALCR Rabbit Polyclonal Antibody
蛋白名称
Calcitonin receptor (CT-R)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P30988
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P30988/entry
Mouse Swissprot No.
Q60755
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60755
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P32214
免疫原
Synthesized peptide derived from human protein . at AA range: 410-490
特异性
CALCR Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009],
组织表达
Amygdala,Kidney,Mammary carcinoma,Ovarian carcinoma,Placenta,
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.,polymorphism:Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.,similarity:Belongs to the G-protein coupled receptor 2 family.,subunit:Interacts with GPRASP2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
