产品名称
AGTR2 Rabbit Polyclonal Antibody
蛋白名称
Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P50052
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P50052/entry
Mouse Swissprot No.
P35374
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P35374
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P35351
免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
AGTR2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010],
组织表达
In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;Renin-angiotensin system;
功能
function:Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with MTUS1.,tissue specificity:In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Very highly expressed in fetal kidney and intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
