产品名称
5HT3B Rabbit Polyclonal Antibody
蛋白名称
5-hydroxytryptamine receptor 3B (5-HT3-B) (5-HT3B) (Serotonin receptor 3B)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O95264
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95264/entry
Mouse Swissprot No.
Q9JHJ5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JHJ5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9JJ16
免疫原
Synthesized peptide derived from human protein . at AA range: 140-220
特异性
5HT3B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011],
组织表达
Expressed in the brain cortex, in the caudate nucleus, the hippocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.
细胞定位
Cell membrane ; Multi-pass membrane protein . Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
功能
function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.,miscellaneous:The HA-stretch region of HTR3B seems to be confer increased conductance to HTR3A/HTR3B heteromers compared to that of HTR3A homomers.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subcellular location:Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.,subunit:Forms a pentaheteromeric complex with HTR3A, homomeric complex being not functional.,tissue specificity:Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
