产品名称
DEF6 Rabbit Polyclonal Antibody
蛋白名称
Defensin-6 (Defensin, alpha 6)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q01524
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q01524/entry
免疫原
Synthesized peptide derived from human protein . at AA range: 51-100
特异性
DEF6 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
defensin alpha 6(DEFA6) Homo sapiens Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014],
组织表达
Expressed in Paneth cells of the small intestine (at protein level).
细胞定位
Secreted . Cytoplasmic vesicle, secretory vesicle . Stored as propeptide in secretory granules of small intestinal Paneth cells and found in the ileum lumen as mature peptide. .
功能
function:Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.,similarity:Belongs to the alpha-defensin family.,subunit:Homodimer.,tissue specificity:Paneth cells of the small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
