产品名称
ZCCHV Rabbit Polyclonal Antibody
基因名称
ZC3HAV1 ZC3HDC2 PRO1677
蛋白名称
Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q7Z2W4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7Z2W4/entry
Mouse Swissprot No.
Q3UPF5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3UPF5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8K3Y6
免疫原
Synthesized peptide derived from human protein . at AA range: 211-260
特异性
ZCCHV Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008],
组织表达
Brain,Endometrium,Epithelium,Fetal liver,Kidney,Ovarian car
细胞定位
[Isoform 1]: Cytoplasm . Nucleus . Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. .; [Isoform 2]: Cytoplasm .
功能
domain:The second and fourth zinc fingers are involved in binding to specific viral RNAs.,function:Induces an innate immunity to viral infections by preventing the accumulation of viral RNAs in the cytoplasm. Seems to recruit the RNA processing exosome to degrade the target RNAs. Inhibits alphavirus and filovirus replication.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 1 WWE domain.,similarity:Contains 4 C3H1-type zinc fingers.,subcellular location:Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.,subunit:Interacts with EXOSC5.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
