产品名称
REEP1 Rabbit Polyclonal Antibody
蛋白名称
Receptor expression-enhancing protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H902
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H902/entry
Mouse Swissprot No.
Q8BGH4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BGH4
免疫原
Synthesized peptide derived from human protein . at AA range: 61-110
特异性
REEP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Mutations in this gene cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009],
组织表达
Expressed in circumvallate papillae and testis.
细胞定位
Membrane . Mitochondrion membrane ; Multi-pass membrane protein . Endoplasmic reticulum . Localizes to endoplasmic reticulum tubular network. .
功能
disease:Defects in REEP1 are the cause of spastic paraplegia autosomal dominant type 31 (SPG31) [MIM:610250]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.,function:May enhance the cell surface expression of odorant receptors.,similarity:Belongs to the DP1 family.,subunit:Interacts with odorant receptor proteins.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
