产品名称
SARM1 Rabbit Polyclonal Antibody
基因名称
SARM1 KIAA0524 SAMD2 SARM
蛋白名称
Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Sterile alpha motif domain-containing protein 2) (SAM domain-containing protein 2) (Tir-1 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6SZW1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6SZW1/entry
Mouse Swissprot No.
Q6PDS3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6PDS3
免疫原
Synthesized peptide derived from human protein . at AA range: 281-330
特异性
SARM1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
caution:Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method.,function:Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.,similarity:Contains 1 TIR domain.,similarity:Contains 2 SAM (sterile alpha motif) domains.,subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function.,tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.,
组织表达
Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta.
细胞定位
Cytoplasm . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse . Mitochondrion . Associated with microtubules. .
功能
caution:Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method.,function:Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.,similarity:Contains 1 TIR domain.,similarity:Contains 2 SAM (sterile alpha motif) domains.,subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function.,tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
