产品名称
PDYN Rabbit Polyclonal Antibody
蛋白名称
Proenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) [Cleaved into: Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1-17) (Dyn-A17) (Dynorphin A); Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin (Dynorphin B) (Dyn-B) (Dynorphin B(1-13)); Leumorphin (Dynorphin B-29)]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P01213
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P01213/entry
Mouse Swissprot No.
O35417
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35417
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P06300
免疫原
Synthesized peptide derived from human protein . at AA range: 201-250
特异性
PDYN Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010],
功能
function:Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.,function:Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.,function:Leumorphin has a typical opiod activity and may have anti-apoptotic effect.,PTM:The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.,similarity:Belongs to the opioid neuropeptide precursor family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
