产品名称
RN135 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase RNF135 (EC 6.3.2.-) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (Riplet)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IUD6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IUD6/entry
Mouse Swissprot No.
Q9CWS1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CWS1
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5M929
免疫原
Synthesized peptide derived from human protein . at AA range: 81-130
特异性
RN135 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
ring finger protein 135(RNF135) Homo sapiens The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
组织表达
Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung.
细胞定位
Cytoplasm . Cytoplasm, Stress granule .
功能
disease:Defects in RNF135 are the cause of RNF135-related overgrowth syndrome. RNF135-related overgrowth syndrome is characterized by overgrowth, learning disability, dysmorphic features and variable additional features.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
