产品名称
CISD2 Rabbit Polyclonal Antibody
基因名称
CISD2 CDGSH2 ERIS ZCD2
蛋白名称
CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8N5K1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N5K1/entry
Mouse Swissprot No.
Q9CQB5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CQB5
免疫原
Synthesized peptide derived from human protein . at AA range: 31-80
特异性
CISD2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011],
组织表达
Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets.
细胞定位
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
功能
caution:Although initially though (PubMed:17846994) to be a zinc-finger protein, it was later shown (PubMed:17376863) that it binds 1 2Fe-2S cluster instead.,cofactor:Binds 1 2Fe-2S cluster.,disease:Defects in CISD2 are the cause of Wolfram syndrome 2 (WFS2) [MIM:604928]. WFS2 is a rare autosomal recessive disorder characterized by characterized by optic atrophy and diabetes mellitus. Other symptoms include the presence of profound upper gastrointestinal ulceration, significant bleeding tendency, defective platelet aggregation with collagen and various neurological symptoms.,function:May play a role in calcium homeostasis.,similarity:Belongs to the CISD protein family.,tissue specificity:Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
