产品名称
ANO10 Rabbit Polyclonal Antibody
蛋白名称
Anoctamin-10 (Transmembrane protein 16K)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NW15
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NW15/entry
Mouse Swissprot No.
Q8BH79
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BH79
免疫原
Synthesized peptide derived from human protein . at AA range: 431-480
特异性
ANO10 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The transmembrane protein encoded by this gene is a member of a family of calcium-activated chloride channels. Defects in this gene may be a cause of autosomal recessive spinocerebellar ataxia-10. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011],
组织表达
Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.
细胞定位
Cell membrane ; Multi-pass membrane protein . Shows predominantly an intracellular localization with a weak expression in the cell membrane.
功能
function:May act as a calcium-activated chloride channel.,sequence caution:Contaminating sequence.,similarity:Belongs to the anoctamin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
