产品名称
ZBP1 Rabbit Polyclonal Antibody
蛋白名称
Z-DNA-binding protein 1 (Tumor stroma and activated macrophage protein DLM-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H171
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H171/entry
Mouse Swissprot No.
Q9QY24
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QY24
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8VDA5
免疫原
Synthesized peptide derived from human protein . at AA range: 21-70
特异性
ZBP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
组织表达
Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen (PubMed:11842111). Expressed to a lesser extent in thymus, lung and liver (PubMed:11842111).
细胞定位
Cytoplasm . Nucleus . Mainly cytoplasmic (PubMed:16876127, PubMed:16990255). Accumulates in the nucleus in response to influenza A virus (IAV) infection: senses IAV defective viral genomes RNA in the nucleus (By similarity). .; [Isoform 7]: Cytoplasm . Nucleus . Compared to isoform 1, a higher proportion of this isoform is localized in the nucleus. .
信号通路
Cytosolic DNA-sensing pathway;
功能
alternative products:Additional isoforms seem to exist,function:May play a role in host defense against tumors and pathogens. Binds Z-DNA.,similarity:Contains 2 DRADA repeats.,tissue specificity:Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
