产品名称
CCDB1 Rabbit Polyclonal Antibody
基因名称
CCNDBP1 DIP1 GCIP HHM
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23582
Human Swissprot No.
O95273
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95273/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17151
Mouse Swissprot No.
Q3TVC7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TVC7
Rat Gene Link
https://www.uniprot.org/uniprot/362201
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5BK06
免疫原
Synthesized peptide derived from human CCDB1 AA range: 53-103
特异性
This antibody detects endogenous levels of CCDB1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009],
组织表达
Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.
功能
developmental stage:Expression may increase during differentiation.,function:May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.,induction:Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation.,PTM:Phosphorylated.,similarity:Belongs to the CCNDBP1 family.,subunit:Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.,tissue specificity:Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
