产品名称
FLVC1 Rabbit Polyclonal Antibody
蛋白名称
Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (hFLVCR)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y5Y0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y5Y0/entry
免疫原
Synthesized peptide derived from human protein . at AA range: 481-530
特异性
FLVC1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011],
组织表达
Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney.
细胞定位
[Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Mitochondrion membrane ; Multi-pass membrane protein .
功能
developmental stage:Down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization. Abundant in fetal liver.,function:Exports cytoplasmic heme. May be required to protect developing erythroid cells from heme toxicity. Causes susceptibility to FeLV-C in vitro.,similarity:Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.,tissue specificity:Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
