产品名称
PZP Rabbit Polyclonal Antibody
蛋白名称
Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P20742
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P20742/entry
免疫原
Synthesized peptide derived from human protein . at AA range: 1301-1350
特异性
PZP Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.,similarity:Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.,subunit:Homotetramer, which consists of two pairs of disulfide-linked chains.,tissue specificity:Plasma. Prominent constituent of late-pregnancy sera.,
组织表达
Plasma. Prominent constituent of late-pregnancy sera.
功能
function:Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.,similarity:Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.,subunit:Homotetramer, which consists of two pairs of disulfide-linked chains.,tissue specificity:Plasma. Prominent constituent of late-pregnancy sera.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
