产品名称
ID2 Rabbit Polyclonal Antibody
蛋白名称
DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q02363
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q02363/entry
Mouse Swissprot No.
P41136
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P41136
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P41137
免疫原
Synthesized peptide derived from human protein . at AA range: 21-70
特异性
ID2 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011],
组织表达
Highly expressed in early fetal tissues, including those of the central nervous system.
细胞定位
Cytoplasm . Nucleus .
功能
developmental stage:Found in most early fetal tissues but not in the corresponding mature tissues.,function:ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Heterodimer with other HLH proteins.,tissue specificity:Highly expressed in early fetal tissues, including those of the central nervous system.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
