产品名称
TIA1 Rabbit Polyclonal Antibody
蛋白名称
Nucleolysin TIA-1 isoform p40 (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P31483
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P31483/entry
Mouse Swissprot No.
P52912
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P52912
免疫原
Synthesized peptide derived from human protein . at AA range: 201-250
特异性
TIA1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008],
组织表达
Expressed in heart, small intestine, kidney, liver, lung, skeletal muscle, testes, pancreas, and ovary (at protein level).
细胞定位
Nucleus . Cytoplasm . Cytoplasm, Stress granule . Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:15371533, PubMed:10613902). Recruitment to SG is induced by Zn(2+) (By similarity). .
功能
function:RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.,PTM:TIA-1 major granule-associated species is a 15-kDa protein (p15-TIA-1) that seems to be derived by proteolytic processing from the C-terminus of p40-TIA-1.,similarity:Contains 3 RRM (RNA recognition motif) domains.,subcellular location:Cytoplasmic granules of cytolytic T-lymphocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
