产品名称
DGAT1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8694
Human Swissprot No.
O75907
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75907/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13350
Mouse Swissprot No.
Q9Z2A7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z2A7
Rat Gene Link
https://www.uniprot.org/uniprot/84497
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ERM3
免疫原
Synthesized peptide derived from human DGAT1 AA range: 405-455
特异性
This antibody detects endogenous levels of DGAT1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013],
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
catalytic activity:Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.,function:Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly.,pathway:Lipid metabolism; glycerolipid metabolism.,similarity:Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
