产品名称
CREL1 Rabbit Polyclonal Antibody
基因名称
CRELD1 CIRRIN UNQ188/PRO214
蛋白名称
Cysteine-rich with EGF-like domain protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96HD1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96HD1/entry
Mouse Swissprot No.
Q91XD7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91XD7
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q4V7F2
免疫原
Synthesized peptide derived from human protein . at AA range: 350-430
特异性
CREL1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a subfamily of epidermal growth factor-related proteins. The encoded protein is characterized by a cysteine-rich with epidermal growth factor-like domain. This protein may function as a cell adhesion molecule. Mutations in this gene are the cause of atrioventricular septal defect. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010],
组织表达
Highly expressed in fetal lung, liver, kidney, adult heart, brain and skeletal muscle. Weakly expressed in placenta, fetal brain, and adult lung, liver, kidney and pancreas.
细胞定位
Membrane ; Multi-pass membrane protein .
功能
alternative products:Additional isoforms seem to exist,disease:Defects in CRELD1 may be the cause of susceptibility to atrioventricular septal defect 2 (AVSD2) [MIM:606217, 600309]. AVSD is a spectrum of cardiac malformations that result in a persistent common atrioventricular canal. The complete form of AVSD involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum. A less severe form, known as partial AVSD or ostium primum atrial septal defect has a deficiency of the atrial septum. Complete AVSD are clinically apparent at birth, whereas less severe forms, such as an isolated cleft mitral valve or small defects of the atrial or ventricular septa may go undetected.,similarity:Belongs to the CRELD family.,similarity:Contains 2 EGF-like domains.,similarity:Contains 2 FU (furin-like) repeats.,tissue specificity:Highly expressed in fetal lung, liver, kidney, adult heart, brain and skeletal muscle. Weakly expressed in placenta, fetal brain, and adult lung, liver, kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
