产品名称
LECT1 Rabbit Polyclonal Antibody
蛋白名称
Leukocyte cell-derived chemotaxin 1 [Cleaved into: Chondrosurfactant protein (CH-SP); Chondromodulin-1 (Chondromodulin-I) (ChM-I)]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75829
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75829/entry
Mouse Swissprot No.
Q9Z1F6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1F6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O70367
免疫原
Synthesized peptide derived from human protein . at AA range: 150-230
特异性
LECT1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularizat
组织表达
Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma.
细胞定位
[Chondromodulin-1]: Secreted, extracellular space, extracellular matrix. Accumulated in the inter-territorial matrix of cartilage.; [Chondrosurfactant protein]: Endomembrane system ; Single-pass membrane protein .
功能
developmental stage:Expressed at 9 weeks in developing cartilagenous bone rudiments.,function:Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development.,PTM:After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.,similarity:Belongs to the chondromodulin-1 family.,similarity:Contains 1 BRICHOS domain.,subcellular location:Accumulated in the inter-territorial matrix of cartilage.,tissue specificity:Cartilage specific. Weakly expressed in chondrosarcoma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
