产品名称
PSME1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5720
Human Swissprot No.
Q06323
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q06323/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19186
Mouse Swissprot No.
P97371
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P97371
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63797
免疫原
Synthesized peptide derived from human PSME1 AA range: 60-110
特异性
This antibody detects endogenous levels of PSME1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
细胞定位
proteasome complex,nucleoplasm,cytoplasm,cytosol,proteasome activator complex,extracellular exosome,
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.,induction:By interferon gamma.,similarity:Belongs to the PA28 family.,subunit:Heterodimer of PSME1 and PSME2, which forms a hexadimeric ring. PSME1 can form homoheptamers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
