产品名称
CLC2D Rabbit Polyclonal Antibody
基因名称
CLEC2D CLAX LLT1 OCIL
蛋白名称
C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UHP7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UHP7/entry
Mouse Swissprot No.
Q91V08
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91V08
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
CLC2D Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010],
组织表达
Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells.
细胞定位
Cell membrane ; Single-pass type II membrane protein .; [Isoform 2]: Endoplasmic reticulum .; [Isoform 4]: Endoplasmic reticulum .
功能
function:Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.,induction:Up-regulated by IL-1alpha and prostaglandin E2 in cultured osteogenic sarcoma cells.,online information:LLT1,similarity:Contains 1 C-type lectin domain.,tissue specificity:Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
