产品名称
SREC Rabbit Polyclonal Antibody
基因名称
SCARF1 KIAA0149 SREC
蛋白名称
Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14162
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14162/entry
Mouse Swissprot No.
Q5ND28
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q5ND28
免疫原
Synthesized peptide derived from human protein . at AA range: 390-470
特异性
SREC Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013],
细胞定位
Membrane ; Single-pass type I membrane protein .
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein.,similarity:Contains 6 EGF-like domains.,subunit:Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL.,tissue specificity:Endothelial cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
