产品名称
AOC3 Rabbit Polyclonal Antibody
蛋白名称
Membrane primary amine oxidase (EC 1.4.3.21) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q16853
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16853/entry
Mouse Swissprot No.
O70423
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70423
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O08590
免疫原
Synthesized peptide derived from human protein . at AA range: 510-590
特异性
AOC3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013],
组织表达
Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung.
细胞定位
Cell membrane ; Single-pass type II membrane protein .
信号通路
Glycine; serine and threonine metabolism;Tyrosine metabolism;Phenylalanine metabolism;beta-Alanine metabolism;
功能
catalytic activity:RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).,cofactor:Binds 1 copper ion per subunit.,cofactor:Binds 2 calcium ions per subunit.,cofactor:Contains 1 topaquinone per subunit.,function:Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity.,PTM:N- and O-glycosylated.,PTM:Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.,similarity:Belongs to the copper/topaquinone oxidase family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed at lower levels in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
