产品名称
B2MG Rabbit Polyclonal Antibody
基因名称
B2M CDABP0092 HDCMA22P
蛋白名称
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P61769
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P61769/entry
Mouse Swissprot No.
P01887
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P01887
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P07151
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
B2MG Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014],
组织表达
Dendritic cell,Eye,Leukemia,Peripheral blood,Skin,Trachea,Urine,
细胞定位
Secreted . Cell surface . Detected in serum and urine (PubMed:1336137, PubMed:7554280). .; (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553). .
信号通路
Antigen processing and presentation;
功能
disease:Defects in B2M are the cause of hypercatabolic hypoproteinemia [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.,function:Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.,online information:Beta-2-microglobulin entry,PTM:Glycation of Ile-21 is observed in long-term hemodialysis patients.,similarity:Belongs to the beta-2-microglobulin family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
