产品名称
FABP5 Rabbit Polyclonal Antibody
蛋白名称
Fatty acid-binding protein, epidermal (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein 5) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q01469
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q01469/entry
Mouse Swissprot No.
Q05816
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q05816
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P55053
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
FABP5 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011],
组织表达
Keratinocytes; highly expressed in psoriatic skin (PubMed:8092987). Expressed in brain gray matter (PubMed:21395585).
细胞定位
Cytoplasm . Nucleus . Cell junction, synapse . Cell junction, synapse, postsynaptic density . Secreted . Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity). .
功能
domain:Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.,function:High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,tissue specificity:Keratinocytes; highly expressed in psoriatic skin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
