产品名称
RMI2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/116028
Human Swissprot No.
Q96E14
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96E14/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/223970
Mouse Swissprot No.
Q3UPE3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UPE3
免疫原
Synthesized peptide derived from human RMI2 AA range: 73-123
特异性
This antibody detects endogenous levels of RMI2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008],
细胞定位
Nucleus . Colocalizes with BLM at nuclear DNA repair foci.
功能
function:Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essential for the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.,PTM:Phosphorylated during mitosis.,similarity:Belongs to the RMI2 family.,similarity:Contains 1 OB DNA-binding domain.,subcellular location:Colocalizes with BLM at nuclear DNA repair foci.,subunit:Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
