产品名称
LGMN Rabbit Polyclonal Antibody
蛋白名称
Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q99538
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99538/entry
Mouse Swissprot No.
O89017
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O89017
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9R0J8
免疫原
Synthesized peptide derived from human protein . at AA range: 60-140
特异性
LGMN Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous. Particularly abundant in kidney, heart and placenta.
信号通路
Lysosome;Antigen processing and presentation;
功能
catalytic activity:Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.,function:Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.,PTM:Glycosylated.,similarity:Belongs to the peptidase C13 family.,tissue specificity:Ubiquitous. Particularly abundant in kidney, heart and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
