产品名称
PTN14 Rabbit Polyclonal Antibody
蛋白名称
Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q15678
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15678/entry
Mouse Swissprot No.
Q62130
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62130
免疫原
Synthesized peptide derived from part region of human protein
特异性
PTN14 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010],
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton . Nucleus. Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
功能
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Expressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
