产品名称
GLMN Rabbit Polyclonal Antibody
基因名称
GLMN FAP48 FAP68 VMGLOM
蛋白名称
Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q92990
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92990/entry
Mouse Swissprot No.
Q8BZM1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BZM1
免疫原
Synthesized peptide derived from human protein . at AA range: 80-160
特异性
GLMN Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
glomulin, FKBP associated protein(GLMN) Homo sapiens This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016],
细胞定位
intracellular,cytoplasm,cullin-RING ubiquitin ligase complex,Cul2-RING ubiquitin ligase complex,Cul3-RING ubiquitin ligase complex,Cul4A-RING E3 ubiquitin ligase complex,
功能
disease:Defects in GLMN are the cause of glomuvenous malformations (GVMs) [MIM:138000]. GVMs are characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens.,function:Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production.,miscellaneous:Rapamycin and FK506 abolish the interaction in a dose dependent manner.,PTM:Phosphorylated on tyrosine residues.,subunit:Monomer. Isoform 1 interacts with notphosphorylated MET and is released upon receptor phosphorylation. Isoform 2 interacts with FKBP59 and FKBP12. Isoform 1 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
