产品名称
PRLR Rabbit Polyclonal Antibody
蛋白名称
Prolactin receptor (PRL-R)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P16471
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P16471/entry
Mouse Swissprot No.
Q08501
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q08501
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P05710
免疫原
Synthesized peptide derived from human protein . at AA range: 80-160
特异性
PRLR Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011],
组织表达
Expressed in breast, placenta, kidney, liver and pancreas.
细胞定位
Membrane ; Single-pass type I membrane protein .; [Isoform 7]: Secreted.
信号通路
Cytokine-cytokine receptor interaction;Neuroactive ligand-receptor interaction;Jak_STAT;
功能
domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoforms 4 and 6 are unable to transduce prolactin signaling.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subcellular location:Isoform 7.,subunit:Interacts with SMARCA1. Interacts with GH1.,tissue specificity:Expressed in breast, placenta, kidney, liver and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
