产品名称
DSC2 Rabbit Polyclonal Antibody
蛋白名称
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q02487
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q02487/entry
Mouse Swissprot No.
P55292
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P55292
免疫原
Synthesized peptide derived from human protein . at AA range: 150-230
特异性
DSC2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015],
组织表达
Expressed in epithelia, myocardium and lymph nodes.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Cell junction, desmosome .
信号通路
Arrhythmogenic right ventricular cardiomyopathy (ARVC);
功能
disease:Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia 11 (ARVD11) [MIM:610476]. Arrhythmogenic right ventricular dysplasia (ARVD) is an inherited myocardial disorder associated with ventricular arrhythmias, heart failure, and sudden death. The main pathologic characteristic of ARVD is loss of myocardium, predominately in the right ventricle, and its replacement with adipose and fibrous tissue. Familial ARVD is believed to account for at least 30%-50% of all cases, although penetrance in some families is estimated to be <30%.,domain:Calcium may be bound by the cadherin-like repeats .,function:Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.,similarity:Contains 5 cadherin domains.,tissue specificity:Expressed in epithelia, myocardium and lymph nodes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
