产品名称
DISP1 Rabbit Polyclonal Antibody
蛋白名称
Protein dispatched homolog 1
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96F81
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96F81/entry
Mouse Swissprot No.
Q3TDN0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3TDN0
免疫原
Synthesized peptide derived from human protein . at AA range: 270-350
特异性
DISP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008],
组织表达
Colon,Kidney,Kidney epithelium,Muscle,Placenta,Testis,
细胞定位
Membrane ; Multi-pass membrane protein .
功能
function:Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the dispatched family.,similarity:Contains 1 SSD (sterol-sensing) domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
