产品名称
KCC2G Rabbit Polyclonal Antibody
基因名称
CAMK2G CAMK CAMK-II CAMKG
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/818
Human Swissprot No.
Q13555
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13555/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12325
Mouse Swissprot No.
Q923T9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q923T9
Rat Gene Link
https://www.uniprot.org/uniprot/171140
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P11730
免疫原
Synthesized peptide derived from human KCC2G AA range: 490-540
特异性
This antibody detects endogenous levels of KCC2G at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011],
组织表达
Expressed in skeletal muscle.
细胞定位
Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
