产品名称
DBLOH Rabbit Polyclonal Antibody
蛋白名称
Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NR28
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NR28/entry
Mouse Swissprot No.
Q9JIQ3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JIQ3
免疫原
Synthesized peptide derived from part region of human protein
特异性
DBLOH Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013],
组织表达
Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.
细胞定位
Mitochondrion . Released into the cytosol when cells undergo apoptosis.
功能
domain:The mature N-terminus mediates interaction with XIAP.,function:Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).,subcellular location:But released into the cytosol when cells undergo apoptosis.,subunit:Interacts with NGFRAP1/BEX3 (By similarity). Homodimer. Interacts with BIRC2, BIRC3, XIAP and BIRC7.,tissue specificity:Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
